李伟

 

 


  

李伟,198011月出生辽宁北镇市人满族中共党员医学博士教授硕士研究生导师澳大利亚昆士兰大学访问学者现任中药材学院院长助理中药学教研室主任为吉林省第五批拔尖创新人才三层次),吉林省首批高校科研春苗人才学校首批青年拔尖创新人才中华中医药学会中药资源学分会委员吉林省药理学会理事吉林省药学会药剂专业委员会和保健食品专业委员会委员吉林省科技特派员中国植物学会和药理学会会员主要从事药用植物资源开发与利用研究工作

近年来先后对人参桔梗五味子等多种长白山药用植物进行化学成分及药理活性研究J Agr Food Chem》,《Food Chem ToxicolPhytotherapy Res等国内外期刊发表学术论文100余篇其中SCI收录70余篇申请发明专利30授权11指导硕士研究生30承担本科生和研究生中药鉴定学中药加工与炮制等课程吉林省优秀课中药鉴定学带头人先后主持国家自然科学基金博士后面上基金和吉林省科技科技发展计划等6项科研课题获得吉林省科技进步三等奖1吉林省自然科学学术成果一等奖1二等奖3长春市级科技进步一等奖和三等奖各1/参编金银花标准化加工与利用》、《中国药用植物志等多部著作及教材

主要工作及学习经历

2000.9-2004.7  吉林农业大学中药材学院中药学专业理学学士学位

2004.9-2007.7  吉林农业大学中药材学院中药学专业医学硕士导师郑毅男教授

2009.7-2012.6  吉林大学白求恩医学院药理学医学博士导师陈立教授

2012.8-2014.8  中国农业科学特产研究所博士后导师王英平研究员

2014.8-2015.8  澳大利亚The University of Queensland, 国家留学基金委公派访问学者

2007.9-至今   吉林农业大学中药材学院讲师(2010),副教授(2014),教授(2016)

三年发表的学术论文

[1] Zhou Yan-dan, Hou Jin-gang, Liu Wei, Ren Shen, Wang Ying-ping, Zhang Rui, Chen Chen, Wang Zi*, Li Wei*. 20(R)-ginsenoside Rg3, a rare saponin from red ginseng, ameliorates acetaminophen-induced hepatotoxicity by suppressing PI3K/AKT pathway-mediated inflammation and apoptosis. International Immunopharmacology, 2018, 59, 21-30. (IF=2.956)

[2] Li Wei*, Chen Chen. Response to the Comments on Caspase-Mediated Anti-Apoptotic Effect of Ginsenoside Rg5, a Main Rare Ginsenoside, on Acetaminophen-Induced Hepatotoxicity in Mice. J Agric Food Chem. 2018, 66(7):1734-1735. (IF=3.154)

[3] Hu Jun-Nan, Xu Xing-Yue, Li Wei*, Wang Yi-Ming, Liu Ying, Wang Zi, Wang Ying-Ping. Ginsenoside Rk1 ameliorates acetaminophen-induced hepatotoxicity in mice through inhibition of inflammation, oxidative stress, nitrative stress and apoptosis. J Ginseng Res, 2017. (IF=4.082)

[4] Hou Jin-gang, Xue Jian-jie, Zhao Xing-hua, Wang Zi, Li Wei*, Li Xin-dian, Zheng Yi-nan. Octyl ester of ginsenoside compound K as novel anti-hepatoma compound: synthesis and evaluation on murine H22 cells in vitro and in vivo, Chem Biol Drug Des, 2018. 91(4):951-956 (IF=2.396)

[5] Ma Zhi-na, Zhi Liu, Wang Zi, Ren Shen, Tang Shan, Wang Ying-ping, Xiao Sheng-yuan, Chen Chen, and Li Wei*. Supplementation of American ginseng berry extract mitigated cisplatin-evoked nephrotoxicity by suppressing ROS-mediated activation of MAPK and NF-κB signaling pathways, Food Chemical Toxicology, 2017.110, 62-73. (IF=3.778)

[6] Wang Zi, Hu Jun-nan, Yan Meng-han, Xing Jing-jing, Liu Wen-cong, Li Wei*. Caspase-mediated anti-apoptotic effect of Ginsenoside Rg5, a main rare ginsenoside, on Acetaminophen-induced Hepatotoxicity in Mice. J Agric Food Chem. 2017, 65(42):9226-9236. (IF=3.154)

[7] Ma Zhi-na, Li Yan-zi, Li Wei*, Yan Xiao-tong, Yang Ge, Zhang Jing, Zhao Li-chun, Yang Li-min. Nephroprotective effects of Saponins from leaves of Panax quinquefolius against cisplatin-induced acute kidney injury. Int. J. Mol. Sci. 2017, 18(7), 1407. (IF=3.226)

[8] Qi Zhen-lan, Wang Zi, Li Wei*, Hou Jin-gang, Liu Ying, Li Xin-dian, Li Hui-ping, Wang Ying-Ping. Nephroprotective effects of Anthocyanins from the fruits of Panax ginseng (GFA) on cisplatin-induced acute kidney injury in mice. Phytotherapy Research. 2017, 31: 1400-1409 (IF=3.095)

[9] Xu Xing-yue, Hu Jun-nan, Liu Zhi, Zhang Rui, He Yu-fang, Hou Wei, Wang Zhi-qing, Yang Ge, Li Wei*. Saponins (ginsenosides) from the Leaves of Panax Quinquefolius Ameliorated Acetaminophen-Induced Hepatotoxicity in Mice. J Agric Food Chem. 2017, 65(18):3684-3692. (IF=3.154)

[10] Hu Jun-Nan, Liu Zhi, Wang Zi, Li Xin-Dian, Zhang Lian-Xue, Li Wei*, Wang Ying-Ping (*). Ameliorative Effects and Possible Molecular Mechanism of Action of Black Ginseng (Panax ginseng) on Acetaminophen-Mediated Liver Injury. Molecules, 2017, 22(4), 664. (IF=2.86)

[11] Liu Zhi, Wang Chong-Zhi, Zhu Xing-You, Wan Jin-Yi, Zhang Jing, Li Wei*, Ruan Chang-Chun (*), Yuan Chun-Su. Dynamic Changes in Neutral and Acidic Ginsenosides with Different Cultivation Ages and Harvest Seasons: Identification of Chemical Characteristics for Panax ginseng Quality Control, Molecules, 2017, 22(5), 734. (IF=2.861)

[12] Han Xin-yue, Hu Jun-nan, Wang Zi, Wei Sheng-nan, Zheng Si-wen, Wang Ying-ping, Li Wei *. 5-HMF Attenuates Liver Fibrosis in CCl4-Plus-Alcohol-Induced Mice by Suppression of Oxidative Stress. Journal of Nutritional Science and Vitaminology, 2017, 63(1):135-143. (IF=0.86)

[13] Li Wei, Yan Meng-Han, Liu Ying, Liu Zhi, Wang Zi, Chen Chen, Zhang Jing, Sun Yin-Shi. Ginsenoside Rg5 Ameliorates Cisplatin-Induced Nephrotoxicity in Mice through Inhibition of Inflammation, Oxidative Stress, and Apoptosis. Nutrients, 2016, 8(9), 566. (IF=3.759)

[14] Li Wei, Tian Yu-Hong, Liu Ying, Wang Zi, Tang Shan, Zhang Jing, Wang Ying-Ping. Platycodin D exerts anti-tumor efficacy in H22 tumor-bearing mice via improving immune function and inducing apoptosis. The Journal of Toxicological Sciences, 2016, 41(3):417-428. (IF=1.29)

[15] Li Wei, Su Xiao-min, Han Ye, Xu Qi, Zhang Jing, Wang Zi, Wang Ying-ping. Maltol, a Maillard reaction product, exerts anti-tumor efficacy in H22 tumor-bearing mice via improving immune function and inducing apoptosis, RSC Adv., 2015, 5(123), 101850-101859. (IF=3.84)

[16] Li Wei, Xu Qi, He Yu-Fang, Liu Ying, Yang Shu-Bao, Wang Zi, Zhang Jing, Zhao Li-Chun. Anti-Tumor Effect of Steamed Codonopsis lanceolata in H22 Tumor-Bearing Mice and Its Possible Mechanism. Nutrients, 2015, 7(10):8294-8307. (IF=3.759)

[17] Li Wei, Liu Ying, Wang Zi, Han Ye, Tian Yu-hong, Zhang Gui-shan, Sun Yin-shi, Wang Ying-ping. Platycodin D isolated from the aerial parts of Platycodon grandiflorum protects alcohol-induced liver injury in mice, Food & Function, 2015, 6(5): 1418-1427. (IF=2.907)

[18] Li Wei, Qu Xin-Nan, Han Ye, Zheng Si-Wen, Wang Jia, Wang Ying-Ping. Ameliorative Effect of 5-hydroxymethyl-2-furfural (5-HMF) on Acute Alcoholic Liver Oxidative Injury in Mice. Int. J. Mol. Sci. 2015, 16(2): 2446-2457. (IF=2.862)

[19] Li Wei, Wang Zi, Gu Jian, Chen Li, Hou Wei, Jin Yin-ping, Wang Ying-ping. Bioconversion of Ginsenoside Rd to ginsenoside M1 by Snailase Hydrolysis and Its Enhancement Effect on Insulin Secretion in vitro, Die Pharmazie, 2015, 70(5):340-346. (IF=1.003)